migraine And cluster headache associated with him The biological clock organizations, according to a new study.

The meta-analysis included 72 studies on how circadian rhythm affects two headache disorders.

The study included data on the time of day or time of year when someone had a headache.

In addition, studies have examined whether specific genes associated with the circadian rhythm are more common in people with these disorders, as well as the hormones cortisol and melatonin associated with the circadian system.

What the study shows

The analysis showed that in 71% in humans, there is a link between cluster headaches and the body’s internal clock—attacks peak late at night and early in the morning and are more common in spring and autumn.

People with cluster headaches also had higher levels of cortisol and lower levels of melatonin than people without the disorder.

With regard to migraine, the analysis showed one seizure pattern related to the internal clock body in 50% people, which fluctuated from late morning to early evening – with a dip at night, when the attacks subsided. Most or the worst migraine attacks did not occur between April and October.

Many genes are associated with the risk of migraine, and it has been found that 110 out of 168 genes are associated with the circadian rhythm..

People with migraine have been found to have lower levels of melatonin in their urine than people without migraine, and these levels were also lower during an attack.

“These data indicate that these two types of headache disorders are highly circadian at multiple levels, especially cluster headache,” said lead researcher Dr. Mike Joseph Burris, who is also a Fellow of the American Academy of Neurology.

As he himself emphasizes, this reinforces the importance of “hypothalamus”, the region of the brain where the main biological “clock” of the body is located, and its role in cluster headache and migraine.

“It also raises questions about the genetics of triggers, such as sleep changes, which are already known to cause migraines and are key to the body’s circadian rhythm,” he adds.

The results of the meta-analysis confirm the possibility of using procedures based on the circadian cycle to treat these disorders, therapies that “may include both circadian rhythm-based therapies, such as taking medications at certain times of the day, and treatments that cause changes in the circadian rhythm, which certain medications are capable of,” the doctor added. Burris.

Source: skynews